Anti-hnRNP U Monoclonal Antibody
品牌：Solarbio | 货号：K000059M
 
 

    

        

            
英文名称
            
Mouse hnRNP U Monoclonal Antibody
        
        

            
应用2
            
WB
        
        

            
克隆类型2
            
Monoclonal Antibody
        
        

            
别名
            
hnRNP U
        
        

            
应用
            
WB
        
        

            
稀释比例
            
WB1:1000
        
        

            
交叉反应
            
Human
        
        

            
蛋白分子量
            
110kDa
        
        

            
Gene ID
            
3192
        
        

            
保存
            
Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.
        
        

            
储存液
            
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 70% Glycerol.
        
        

            
纯化方法
            
Affinity purification
        
        

            
亚型
            
IgG1
        
        

            
免疫原
            
Purified recombinant human hnRNP U protein fragments expressed in E.coli.
        
        

            
性状
            
Lyophilized or Liquid
        
        

            
Swiss Prot
            
Q00839
        
        

            
克隆号
            
1B11-H2-B7
        
        

            
克隆类型
            
Monoclonal Antibody
        
        

            
来源
            
Mouse
        
        

            
背景资料
            
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]