Anti-Dynactin 1(N-term) Monoclonal Antibody
产品名称： Anti-Dynactin 1(N-term) Monoclonal Antibody
英文名称： Anti-Dynactin 1(N-term) Monoclonal Antibody
产品编号： K000007M
产品价格： null
产品产地： 北京
品牌商标： Solarbio
更新时间： 2025-01-13T13:42:34
使用范围： WB IP
北京索莱宝科技有限公司
- 联系人 : 索莱宝-龚思雨
- 地址 : 北京市通州区中关村科技园区通州园金桥科技产业基地景盛南四街15号85A三层
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Anti-Dynactin 1(N-term) Monoclonal Antibody
品牌：solarbio | 货号：K000007M
英文名称 Anti-Dynactin 1(N-term) Monoclonal Antibody 宿主 Mouse 别名 DAP-150;DP-150;P135 应用 WB IP 稀释比例 WB 1:500. 交叉反应 Human 蛋白分子量 150kDa Gene ID 1639 保存 Store at -20°C. Avoid freeze / thaw cycles. 储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. 纯化方法 Affinity purification 亚型 IgG2b 免疫原 Purified recombinant Dynactin 1 protein fragments
expressed in E.coli性状 液体 Public
Immunogen
RangePurified recombinant Dynactin 1 protein fragments
expressed in E.coliSubcellular
LocationsCytoplasm cytoskeleton Swiss Prot Q14203 克隆号 3D5-C6-D5 克隆类型 Monoclonal Antibody 背景资料 This gene encodes the largest subunit of dynactin,a
macromolecular complex consisting of 10 subunits
ranging in size from 22 to 150kD.Dynactin binds to both
microtubules and cytoplasmic dynein.Dynactin is
involved in a diverse array of cellular functions,including
ER-to-Golgi transport,the centripetal movement of
lysosomes and endosomes,spindle
formation,chromosome movement,nuclear positioning,
and axonogenesis.This subunit interacts with dynein
intermediate chain by its domains directly binding to
dynein and binds to microtubules via a highly conserved
glycine-rich cytoskeleton-associated protein (CAP-Gly)
domain in its N-terminus.Alternative splicing of this gene
results in multiple transcript variants encoding distinct
isoforms.Mutations in this gene cause distal hereditary
motor neuronopathy type VIIB (HMN7B) which is also
known as distal spinal and bulbar muscular atrophy
(dSBMA).[provided by RefSeq, Oct 2008]